When a deadly virus breaks out in Seattle, nine thousand people die, while thousands more gain remarkable new abilities. The disaster leaves Jordan Collier, the charismatic leader of The 4400 Movement, in charge of the city, but an international conspiracy will stop at nothing to bring him down. NTAC agents Tom Baldwin and Diana Skouris find themselves caught in the middle as they try to save Seattle from both Jordan and his enemies, with the future of the planet hanging in the balance.