This is the story of the great paradigm shifts of science, told as never before: in Sherlock Holmes adventures set amid the grandeur and squalor of Victorian London. The first stories involve the overthrow of ancient fallacies. Subsequent cases turn on problems of relative motion and timing. More subtle crimes relate to quantum effects. The strangest story is based on real life: a physicist at the Santa Fe Institute was challenged to prove his faith in a widely accepted interpretation of quantum theory in the only way possible by taking part in a bizarre game of Russian roulette. Here the challenge is accepted....