After their pa falls deathly ill with smallpox, Jimmy and his sister, Hour, travel into Deadwood, South Dakota to seek help. While their pa is in quarantine, the two form unbreakable bonds with the surrogate family that emerges from the tragedy of loss. In a place where life is fragile and families are ripped apart by disease, death, and desperation, a surprising collection of Deadwood's inhabitants surround Jimmy, Hour, and Jane. There, in the most unexpected of places, they find a family protecting them from the uncertainty and chaos that surrounds them all.